Men with stigmata are known as Limiters, and women are known as Pandoras. The only hope of survival against them are stigmata implanted men and women.
It is set in a distant future and revolves around the threat of the Novas, a monstrous alien race that attacks humanity causing cause death and destruction. ‘Freezing’ kind of capitalizes on that principle. But then the anime tries to push in little hope in the form of certain humans training to defeat those powerful enemies. Monsters or aliens are gonna run wild and destroy our existence. Most anime makes it seem like the future is going to be worse than anything.